Sodium NMR relaxation times of human skin as potential biomarkers for Type 2 Diabetes Mellitus

Авторы: Fomina D.V., Sadykhov E.G., Hanson P., Philp C.J., Randeva H.S., O'Hare J.P., Pavlova O.S., Anisimov N.V., Makurenkov A.M., Pirogov Y.A., Barber T.M., Meersmann T., Pavlovskaya G.E.
Сборник: Proc. Intl. Soc. Mag. Reson. Med
Том: 29
Год издания: 2021
Номер статьи: 1791
Аннотация: Skin plays an important role in sodium regulation in the human body. As sodium interaction with macromolecules in biological tissue results in a biexponential T2 relaxation, a sensitive characterization of the molecular environment of the sodium ions can be made. This allows us to investigate sodium relaxation times, T2short and T2long, in human skin samples from patients with and without Type 2 Diabetes Mellitus (T2DM) using highresolution 23Na MRS at high field 9.4 T. We find that there is a significant elongation of T2long in T2DM patients. This might be indicative of disease specific skin structure changes.
Добавил в систему: Анисимов Николай Викторович

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