Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues

Efremov, Y.M.; Zurina, I.M.; Presniakova, V.S.; Kosheleva, N.V.; Butnaru, D.V.; Svistunov, A.A.; Rochev, Y.A.; Timashev, P.S.

Авторы: Efremov Yuri M., Zurina Irina M., Presniakova Viktoria S., Kosheleva Nastasia V., Butnaru Denis V., Svistunov Andrey A., Rochev Yury A., Timashev Peter S.
Журнал: Biophysical Reviews
Год издания: 2021
Издательство: Springer Verlag
Местоположение издательства: Germany
DOI: 10.1007/s12551-021-00821-w
Аннотация: Cell aggregates, including sheets and spheroids, represent a simple yet powerful model system to study both biochemical and biophysical intercellular interactions. However, it is becoming evident that, although the mechanical properties and behavior of multicellular structures share some similarities with individual cells, yet distinct differences are observed in some principal aspects. The description of mechanical phenomena at the level of multicellular model systems is a necessary step for understanding tissue mechanics and its fundamental principles in health and disease. Both cell sheets and spheroids are used in tissue engineering, and the modulation of mechanical properties of cell constructs is a promising tool for regenerative medicine. Here, we review the data on mechanical characterization of cell sheets and spheroids, focusing both on advances in the measurement techniques and current understanding of the subject. The reviewed material suggest that interplay between the ECM, intercellular junctions, and cellular contractility determines the behavior and mechanical properties of the cell aggregates.
Добавил в систему: Тимашев Петр Сергеевич

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Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissuesстатья

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