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New Fe-Cu bimetallic coordination compounds based on ω-ferrocene carboxylic acids and 2-thioimidazol-4-ones: structural, mechanistic and biological studiesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 ноября 2021 г.
- Авторы: Guk Dmitry A., Krasnovskaya Olga O., Moiseeva Anna A., Tafeenko Viktor, Ul’yanovskii Nikolay, Kosyakov Dmitry, Pergushov Vladimir I., Melnikov Mikhail Ya, Zyk Nikolai, Skvortsov Dmitry A., Lopatukhina Elena, Vaneev Alexander N., Gorelkin Petr, Erofeev Alexander, Majouga Alexander, Beloglazkina Elena K.
- Журнал: INORGANIC CHEMISTRY FRONTIERS
- Том: 8
- Год издания: 2021
- Первая страница: 4730
- Последняя страница: 4750
- DOI: 10.1039/d1qi00714a
- Аннотация: Synthesis, characterization (HRMS, NMR, EPR, UV-Vis spectroscopy, and electrochemistry) and in vitro cytotoxic investigation of a series of new ferrocene-containing derivatives, based ω-ferrocene carboxylic acids and 2-alkylthioimidazol-4-ones as well as their copper coordination compounds have been reported. A series of ferrocene-imidazolone conjugates with different lengths and donor properties of the linker fragments have been synthesized; all obtained compounds were studied in complexation reactions with copper(I) and copper(II) perchlorates.It is shown that synthesised conjugatesare rapidly and efficiently convert coordinating copper ions into the Cu(+1) oxidation state, but a change in the length of the linker in ferrocene-imidazolone ligands fundamentally changes the ratio of products formed as a result of iron oxidation/copper reduction and complexation by various mechanisms. After comparing the data on the qualitative and quantitative composition of the reaction mixtures and the kinetic characteristics of the processes occurring in the mixtures of ferrocene-imidazolones with copper(II) perchlorate, a scheme of the ongoing reactions was proposed that may fully explain all the observed processes and products. It has been shown that the obtained bimetallic Cu/Fe coordination compounds are more toxic than cisplatin and induce apoptosis in micromolar concentrations on Hek-293 and MCF-7 cell lines.
- Добавил в систему: Белоглазкина Елена Кимовна