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SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itselfстатья Электронная публикация
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 сентября 2021 г.
- Авторы: Ferreira-Gomes Marta, Kruglov Andrey, Durek Pawel, Heinrich Frederik, Tizian Caroline, Heinz Gitta Anne, Pascual-Reguant Anna, Du Weijie, Mothes Ronja, Fan Chaofan, Frischbutter Stefan, Habenicht Katharina, Budzinski Lisa, Ninnemann Justus, Jani Peter K., Guerra Gabriela Maria, Lehmann Katrin, Matz Mareen, Ostendorf Lennard, Heiberger Lukas, Chang Hyun-Dong, Bauherr Sandy, Maurer Marcus, Schönrich Günther, Raftery Martin, Kallinich Tilmann, Mall Marcus Alexander, Angermair Stefan, Treskatsch Sascha, Dörner Thomas, Corman Victor Max, Diefenbach Andreas, Volk Hans-Dieter, Elezkurtaj Sefer, Winkler Thomas H., Dong Jun, Hauser Anja Erika, Radbruch Helena, Witkowski Mario, Melchers Fritz, Radbruch Andreas, Mashreghi Mir-Farzin
- Журнал: Nature communications
- Том: 12
- Год издания: 2021
- Издательство: Nature Pub. Group
- Местоположение издательства: United Kingdom
- Номер статьи: 1961
- DOI: 10.1038/s41467-021-22210-3
- Аннотация: The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care. Before seroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display a type 1 interferon-induced gene expression signature; however, following seroconversion, plasmablasts lose this signature, express instead gene signatures induced by IL-21 and TGF-β, and produce mostly IgG1 and IgA1. In the sustained immune reaction from COVID-19 patients, plasmablasts shift to the expression of IgA2, thereby reflecting an instruction by TGF-β. Despite their continued presence in the blood, plasmablasts are not found in the lungs of deceased COVID-19 patients, nor does patient IgA2 binds to the dominant antigens of SARS-CoV-2. Our results thus suggest that, in severe COVID-19, SARS-CoV-2 triggers a chronic immune reaction that is instructed by TGF-β, and is distracted from itself.
- Добавил в систему: Круглов Андрей Алексеевич