Аннотация:Intravenous administration of recombinant Destabilase is
followed by thrombi slow (> 24h) dissolution. Degree of thrombolysis
stimulated by Destabilase was higher than by Streptokinase, clinical
thrombolytic agent. In similar setting, degree of lysis was higher for arterial
vs. venous thrombi. Degradation of isopeptide bonds by Destabilase was a
crucial parameter for stabilized fibrin lysis. It results in slow spontaneous
transition of the old thrombi from solid to soluble state. Thus, Destabilase is
able to perform thrombolysis independent of proteolysis.