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SOME OXIDATIVE STRESS INDICATORS CHANGES IN TYPE 1 DIABETES MELLITUS PATIENTS AT THE PRECLINICAL STAGE OF DIABETIC NEPHROPATHY.. 2021. Т. 23. № S2. С. 235.статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 15 сентября 2021 г.
- Авторы: Chugunova E.V., Darenskaya M.A., Semenova Nv, Kolesnikova L.I., Kolesnikov S.I.
- Журнал: Diabetes Technology and Therapeutics
- Том: 23
- Номер: s2
- Год издания: 2021
- Издательство: Mary Ann Liebert Inc.
- Местоположение издательства: United States
- Первая страница: 235
- Последняя страница: 235
- DOI: 10.1089/dia.2021.2525.abstracts
- Аннотация: Background and Aims: Diabetes mellitus (DM) is one of the most common socially significant nosology. At present, there is practically no information about changes in the parameters of cellular metabolism at the preclinical stages of diseases, in particular for type 1 diabetes mellitus (T1DM), which pathogenesis is closely associated with oxidative stress reactions. Aim: to study some oxidative stress indicators changes in men with T1DM at the diabetic nephropathy preclinical stage.Methods: A survey of 28 men with T1DM with unsatisfactory glycemic control was carried out. The patients were divided into two groups ‐ 14 people with normoalbuminuria (NAU) ‐ and 14 people with a positive test for microalbuminuria (MAU). As a control, 28 practically healthy men of the same age were selected. Spectrophotometric and statistical methods were used.Results: In patients with T1DM and NAU, the level of compounds with unsaturated double bonds (DB) (by 1.98 times), diene conjugates (DC) (by 2.34 times), ketodienes and conjugated trienes (KD and CT) (by 2.75 times), were significantly higher than in the control (p < 0.05). In patients with T1DM and MAU, an increase in DB (by 1.48 times), DC (by 2.09 times), KD and CT (by 2.25 times) relative to the control (p < 0.05) values also were noted. At the same time, the group with MAU differed from the NAU group by thiobarbituric acid reactants products higher values.Conclusions: According to indicators of oxidative stress, T1DM patients require increased attention, regardless of the albuminuria level.
- Добавил в систему: Колесников Сергей Иванович