Insulin-Like Growth Factors (IGF) and IGF-Binding Proteins (IGFBP) in the Serum of Patients with Ovarian Tumorsстатья
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Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
Авторы:
Gershtein E.S. ,
Isaeva E.R.,
Kushlinsky D.N. ,
Korotkova E.A. ,
Ermilova V.D. ,
Laktionov K.P. ,
Adamyan L.V.
Журнал:
Bulletin of Experimental Biology and Medicine
Том:
160
Номер:
6
Год издания:
2016
Издательство:
Springer Nature
Местоположение издательства:
Switzerland
Первая страница:
814
Последняя страница:
816
DOI:
10.1007/s10517-016-3317-2
Аннотация:
IGF-1, IGF-2, and IGFBP-1,2,3 were assayed in blood serum of patients with malignant ovarian tumors (n=44), borderline ovarian tumors (n=11), and benign ovarian tumors (n=12) as well as in healthy women (n=33). In blood serum of patients with malignant ovarian tumors, the level of IGF-1 was lower and IGFBP-1 was higher than in other groups. In patients with malignant and borderline ovarian tumors, the level of IGFBP-2 was higher than in healthy women and in patients with benign ovarian tumors. There was no correlation between most examined parameters and the clinical and morphological peculiarities of ovarian tumors. The study revealed IGF/IGFBP imbalance in patients with malignant ovarian tumor and showed that IGFBP-2 proved to be a potential diagnostic serological marker w with 90% sensitivity and 90% specificity. В© 2016, Springer Science+Business Media New York.
Добавил в систему:
Герштейн Елена Сергеевна