Аннотация:Laser fluorescence spectroscopy (LFS) is widely used in medicine. Today, oncology and oncosurgery areconsidered as the most promising fields of its application. It is known that cancerous tissues are able toaccumulate different porphyrins, both endogenous and exogenous, in enhanced amount due to increasedmetabolism in cancerous cells. So, LFS can be used in vivo for detection of malignant tumours as well as forreal-time intraoperative imaging or diagnostics at a photodynamic therapy. One of the reason of theenhanced accumulation of porphyrins in tissues is a chronic hypoxia. Therefore, it was hypothesized, thatLFS could also be used for diagnosis of local inflammation in tissues. Recently, some indirect dataconfirming the hypothesis was obtained when observed inflammation due to invasion of external substancesinto tissues. This study proves the hypothesis in a direct experiment with animals and laboratory tests.Enhanced fluorescence intensity of the exogenous photosensitizer was found in inflamed tissues. The directassociation between intensity of the fluorescence, histological characteristics and blood test results wasshown. It was found that the registered fluorescence signal correlates with neutrophil counts in blood oftested animals. It proves that LFS could be an effective tool for registration of local inflammation.