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Vanadium(IV) Complexes with Methyl‐Substituted 8‐Hydroxyquinolines: Catalytic Potential in the Oxidation of Hydrocarbons and Alcohols with Peroxides and Biological Activityстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 декабря 2021 г.
- Авторы: Palion‐Gazda Joanna, Luz André, Raposo Luis R., Choroba Katarzyna, Nycz Jacek E., Bieńko Alina, 4 Agnieszka Lewińska, 5 Karol Erfurt, Baptista Pedro V., Machura Barbara, Fernandes * Alexandra R., Shul’pina Lidia S., Ikonnikov Nikolay S., Shul’pin Georgiy B.
- Журнал: Molecules
- Том: 26
- Номер: 21
- Год издания: 2021
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 6364
- DOI: 10.3390/molecules26216364
- Аннотация: Methyl‐substituted 8‐hydroxyquinolines (Hquin) were successfully used to synthetizefive‐coordinated oxovanadium(IV) complexes: [VO(2,6‐(Me)2‐quin)2] (1), [VO(2,5‐(Me)2‐quin)2] (2)and [VO(2‐Me‐quin)2] (3). Complexes 1–3 demonstrated high catalytic activity in the oxidation ofhydrocarbons with H2O2 in acetonitrile at 50 °C, in the presence of 2‐pyrazinecarboxylic acid (PCA)as a cocatalyst. The maximum yield of cyclohexane oxidation products attained was 48%, which ishigh in the case of the oxidation of saturated hydrocarbons. The reaction leads to the formation of amixture of cyclohexyl hydroperoxide, cyclohexanol and cyclohexanone. When triphenylphosphineis added, cyclohexyl hydroperoxide is completely converted to cyclohexanol. Consideration of theregio‐ and bond‐selectivity in the oxidation of n‐heptane and methylcyclohexane, respectively,indicates that the oxidation proceeds with the participation of free hydroxyl radicals. The complexesshow moderate activity in the oxidation of alcohols. Complexes 1 and 2 reduce the viability ofcolorectal (HCT116) and ovarian (A2780) carcinoma cell lines and of normal dermal fibroblastswithout showing a specific selectivity for cancer cell lines. Complex 3 on the other hand, shows ahigher cytotoxicity in a colorectal carcinoma cell line (HCT116), a lower cytotoxicity towards normaldermal fibroblasts and no effect in an ovarian carcinoma cell line (order of magnitude HCT116 >fibroblasts > A2780).
- Добавил в систему: Шульпина Лидия Сергеевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | molecules-26-06364-Machura.pdf | 1,0 МБ | 22 октября 2021 [ShulpinaLS.] | |
| 2. | экспертное заключение | CCF11112021.pdf | 413,4 КБ | 11 ноября 2021 [ShulpinaLS.] |