Efficient Multicomponent Synthesis of α-Trifluoromethyl Proline, Homoproline, and Azepan Carboxylic Acid Dipeptidesстатья
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Дата последнего поиска статьи во внешних источниках: 19 июля 2013 г.
Аннотация:Cyclic imines bearing CF3 and C2F5 group were successfully used for the first Ugi multicomponent synthesis of polyfluoroalkyl-substituted proline, homoproline, and azepan carboxylic acid derivatives. Based on the suggested reaction the first synthesis of dipeptides containing α-CF3 cyclic amino acids residue was described. The scope and limitations of the approach are discussed.