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Chronic cocaine treatment attenuates the behavioral response of kappa-opioid receptor systems to the agonist U-50,488Hстатья
- Авторы: Kudryavtseva N.N., Gerrits M.A., Alekseyenko O.V., Van Ree J.M.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 406
- Номер: 2
- Год издания: 2005
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 1
- Последняя страница: 3
- DOI: 10.1007/s10517-005-0479-8
- Аннотация: Chronic injections of cocaine (20 mg/kg daily for 10 days) increase activity and decrease anxiety in male C57Bl/6j mice in comparison with animals chronically injected with normal saline. U-50,488H (kappa-opioid receptor agonist; 2.5 mg/kg) produced an anxiolytic effect in animals preinjected with normal saline and had no effect in animals chronically injected with cocaine. Presumably, chronic activation of dopaminergic systems caused by cocaine injections is paralleled by desensitization of kappa-opioid receptor system.
- Добавил в систему: Галямина Анна Георгиевна