EARLY MORPHOLOGICAL CHANGES IN TISSUES WHEN REPLACING ABDOMINAL WALL DEFECTS BY BACTERIAL NANOCELLULOSE IN EXPERIMENTAL TRIALS

Жариков, А.Н.; Лубянский, В.Г.; Гладышева, Е.К.; Скиба, Е.А.; Будаева, В.В.; Семенова, Е.Н.; Жариков, А.А.; Сакович, Г.В.

Авторы: Жариков А.Н., Лубянский В.Г., Гладышева Е.К., Скиба Е.А., Будаева В.В., Семенова Е.Н., Жариков А.А., Сакович Г.В.
Журнал: Journal of materials science. Materials in medicine
Том: 29
Номер: 7
Год издания: 2018
Издательство: SPRINGER
Местоположение издательства: VAN GODEWIJCKSTRAAT 30, DORDRECHT, NETHERLANDS, 3311GZ
Первая страница: 95
DOI: 10.1007/s10856-018-6111-z
Аннотация: Experimental trials were done on five dogs to explore if an anterior abdominal wall defect could be repaired using wet(99.9%), compact BNC membranes produced by the Мedusomyces gisevii Sa-12 symbiotic culture. The abdominal walldefect was simulated by middle-midline laparotomy, and a BNC membrane was then fixed to open aponeurotic edges withblanket suture (Prolene 4-0, Ethicon). A comparative study was also done to reinforce the aponeurotic defect with both theBNC membrane and polypropylene mesh (PPM) (Ultrapro, Ethicon). The materials were harvested at 14 and 60 dayspostoperative to visually evaluate their location in the abdominal tissues and evaluate the presence of BNC and PPMadhesions to the intestinal loops, followed by histologic examination of the tissue response to these prosthetics. The BNCexhibited good fixation to the anterior abdominal wall to form on the 14th day a capsule of loose fibrin around the BNC.Active reparative processes were observed at the BNC site at 60 days post-surgery to generate new, stable connective-tissueelements (macrophages, giant cells, fibroblasts, fibrin) and neocapillaries. Negligible intraperitoneal adhesions were detectedbetween the BNC and the intestinal loops as compared to the case of PPM. There were no suppurative complicationsthroughout the postsurgical period. We noticed on the 60th day after the BNC placement that collagenous elements and newcapillary vessels were actively formed in the abdominal wall tissues, generating a dense postoperative cicatrix whoseintraperitoneal adhesions to the intestinal loops were insignificant compared to the PPM graft
Добавил в систему: Щанкин Михаил Владимирович

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EARLY MORPHOLOGICAL CHANGES IN TISSUES WHEN REPLACING ABDOMINAL WALL DEFECTS BY BACTERIAL NANOCELLULOSE IN EXPERIMENTAL TRIALSстатья