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Anti-inflammatory Effect of the Peptide LKEKKстатья
- Авторы: Navolotskaya E.V., Sadovnikova V.B., Zinchenko D.V., Zav’yalov V.P., Murashev A.N.
- Журнал: Journal of Clinical & Experimental Immunology
- Том: 6
- Номер: 5
- Год издания: 2021
- Издательство: OPAST GROUP LLC
- Местоположение издательства: Overland Park, KS, USA
- Первая страница: 356
- Последняя страница: 361
- DOI: 10.33140/jcei.06.05.02
- Аннотация: We have established that the peptide LKEKK (Np5) corresponding to the sequence 16-20 of thymosin-α1 and to the sequence 131-135 of interferon-α2, in the concentration range 50 300 μg/ear reduces in a dose-dependent manner phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice .Tested in parallel peptide with inverted sequence (iNp5, KKEKL, 150-300 μg/ear) was inactive, indicating high specificity of the Np5 action. In the concentration range of 5 20 μM Np5 significantly decrease the TNF-α-induced production by normal human keranocytes of pro-inflammatory mediators IL-6 and IL-1β. Thus, Np5t has a pronounced anti-inflammatory activity in vivo and in vitro.
- Добавил в систему: Зинченко Дмитрий Валерьевич