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Mitophagy in carcinogenesis and cancer treatmentстатья Электронная публикация
- Авторы: Denisenko Tatiana V., Gogvadze Vladimir, Zhivotovsky Boris
- Журнал: Discover Oncology
- Том: 12
- Номер: 1
- Год издания: 2021
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- DOI: 10.1007/s12672-021-00454-1
- Аннотация: In order to maintain a functional mitochondrial network, cells have developed a quality control mechanism, namelymitophagy. This process can be induced through diferent pathways. The most studied is the so-called PINK1/Parkinpathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be relatedto Parkinson’s disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins,such as BNIP3 and BNIP3L, also known as Nix. Through these two mechanisms, mitophagy fulflls its functions and maintains cellular homeostasis. Here, we summarize the current knowledge about the mechanisms of mitophagy regulationand their interplay with cancer progression as well as anticancer treatment.
- Добавил в систему: Денисенко Татьяна Викторовна