A Balance Between Autophagy and Other Cell Death Modalities in Cancer

Авторы: Gorbunova Anna S., Kopeina Gelina S., Zhivotovsky Boris
Сборник: Methods in Molecular Biology
Серия: Autophagy and Cancer
Том: 2445
Год издания: 2022
Издательство: Humana Press, Inc.
Местоположение издательства: United States
Первая страница: 3
Последняя страница: 24
DOI: 10.1007/978-1-0716-2071-7_1
Аннотация: Autophagy is an intracellular self-digestive process involved in catabolic degradation of damaged proteins, and organelles, and the elimination of cellular pathogens. Initially, autophagy was considered as a prosurvival mechanism, but the following insights shed light on its prodeath function. Nowadays, autophagy is established as a crucial player in the development of various diseases through interaction with other molecular pathways within a cell. Additionally, disturbance in autophagy is one of the main pathological alterations that lead to resistance of cancer cells to treatment. These autophagy-related pathologies gave rise to the development of new therapeutic drugs. Here, we summarize the current knowledge on the autophagic role in disease pathogenesis, particularly in cancer, and the interplay between autophagy and other cell death modalities in order to combat cancer.
Добавил в систему: Горбунова Анна Сергеевна

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