SARS-CoV-2 specific T cells and antibodies in COVID-19 protection: a prospective study

Molodtsov, I.A.; Kegeles, E.; Mitin, A.N.; Mityaeva, O.; Musatova, O.E.; Panova, A.E.; Pashenkov, M.V.; Peshkova, I.O.; Almaqdad, A.; Asaad, W.; Budikhina, A.S.; Deryabin, A.S.; Dolzhikova, I.V.; Filimonova, I.N.; Gracheva, A.N.; Ivanova, O.I.; Kizilova, A.; Komogorova, V.V.; Komova, A.; Kompantseva, N.I.; Lagutkin, D.A.; Lomakin, Y.A.; Maleeva, A.V.; Maryukhnich, E.V.; Mohammad, A.; Murugin, V.V.; Murugina, N.E.; Navoikova, A.; Nikonova, M.F.; Ovchinnikova, L.A.; Pinegina, N.V.; Potashnikova, D.M.; Romanova, E.V.; Saidova, A.A.; Sakr, N.; Samoilova, A.G.; Serdyuk, Y.; Shakirova, N.T.; Sharova, N.I.; Sheetikov, S.A.; Shemetova, A.F.; Shevkova, L.; Shpektor, A.V.; Trufanova, A.; Tvorogova, A.V.; Ukrainskaya, V.M.; Vinokurov, A.S.; Vorobyeva, D.A.; Zornikova, K.V.; Efimov, G.A.; Khaitov, M.R.; Kofiadi, I.A.; Komissarov, A.A.; Logunov, D.Y.; Naigovzina, N.B.; Rubtsov, Y.P.; Vasilyeva, I.A.; Volchkov, P.; Vasilieva, E.

Авторы: Molodtsov Ivan A., Kegeles Evgenii, Mitin Alexander N., Mityaeva Olga, Musatova Oksana E., Panova Anna E., Pashenkov Mikhail V., Peshkova Iuliia O., Almaqdad Alsalloum, Asaad Walaa, Budikhina Anna S., Deryabin Aleksander S., Dolzhikova Inna V., Filimonova Ioanna N., Gracheva Alexandra N., Ivanova Oxana I., Kizilova Anastasia, Komogorova Viktoria V., Komova Anastasia, Kompantseva Natalia I., Lagutkin Denis A., Lomakin Yakov A., Maleeva Alexandra V., Maryukhnich Elena V., Mohammad Afraa, Murugin Vladimir V., Murugina Nina E., Navoikova Anna, Nikonova Margarita F., Ovchinnikova Leyla A., Pinegina Natalia V., Potashnikova Daria M., Romanova Elizaveta V., Saidova Aleena A., Sakr Nawar, Samoilova Anastasia G., Serdyuk Yana, Shakirova Naina T., Sharova Nina I., Sheetikov Savely A., Shemetova Anastasia F., Shevkova Liudmila, Shpektor Alexander V., Trufanova Anna, Tvorogova Anna V., Ukrainskaya Valeria M., Vinokurov Anatoliy S., Vorobyeva Daria A., Zornikova Ksenia V., Efimov Grigory A., Khaitov Musa R., Kofiadi Ilya A., Komissarov Alexey A., Logunov Denis Y., Naigovzina Nelli B., Rubtsov Yury P., Vasilyeva Irina A., Volchkov Pavel, Vasilieva Elena
Сборник: Medrxiv
Год издания: 2021
Издательство: Cold Spring Harbor Laboratory Press
Местоположение издательства: United States
DOI: 10.1101/2021.08.19.21262278
Аннотация: Rapid spread of COVID-19 pandemic made a substantial share of the world population immunised by SARS-CoV-2 antigens. Infection induces the development of virus-specific antibodies and T cells. Ample evidence on the antibody-mediated protection is contrasted by the elusive role of T cells in preventing infection. To explore the impact of T cells and to quantify the protective levels of the immune responses we conducted a large prospective study: 5,340 Moscow residents were evaluated for the antibody and cellular immune responses to SARS-CoV-2 and monitored for COVID-19 up to 300 days. The antibody and cellular responses were tightly interconnected, their magnitude inversely correlated with infection probability. Similar maximal level of protection was reached by individuals positive for both types of responses and by individuals with antibodies alone. Meanwhile, T cells in the absence of antibodies provided an intermediate level of protection. The real-world data on the protective effects of T cells have important implications for T cell immunology and development of the strategies to fight the pandemic.
Добавил в систему: Шитиков Савелий Андреевич

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SARS-CoV-2 specific T cells and antibodies in COVID-19 protection: a prospective studyстатья