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Injectable bottlebrush hydrogels with tissue-mimetic mechanical propertiesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: VASHAHI FOAD, MARTINEZ MICHAEL R., DASHTIMOGHADAM ERFAN, FAHIMIPOUR FARAHNAZ, KEITH ANDREW N., BERSENEV EGOR A., IVANOV DIMITRI A., ZHULINA EKATERINA B., POPRYADUKHIN PAVEL, MATYJASZEWSKI KRZYSZTOF, VATANKHAH-VARNOSFADERANI MOHAMMAD, SHEIKO SERGEI S.
- Журнал: Science Advances
- Том: 8
- Номер: 3
- Год издания: 2022
- DOI: 10.1126/sciadv.abm2469
- Аннотация: Injectable hydrogels are desired in many biomedical applications due to their minimally invasive deployment to the body and their ability to introduce drugs. However, current injectables suffer from mechanical mismatch with tissue, fragility, water expulsion, and high viscosity. To address these issues, we design brush-like macromolecules that concurrently provide softness, firmness, strength, fluidity, and swellability. The synthesized linear-bottlebrush-linear (LBL) copolymers facilitate improved injectability as the compact conformation of bottlebrush blocks results in low solution viscosity, while the thermoresponsive linear blocks permit prompt gelation at 37°C. The resulting hydrogels mimic the deformation response of supersoft tissues such as adipose and brain while withstanding deformations of 700% and precluding water expulsion upon gelation. Given their low cytotoxicity and mild inflammation in vivo, the developed materials will have vital implications for reconstructive surgery, tissue engineering, and drug delivery applications.
- Добавил в систему: Иванов Дмитрий Анатольевич