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Fas Role in Ischemic Stroke: Not Only in Apoptosisстатья
- Авторы: Sergeeva SP, Gorbacheva LR, Breslavich ID, Cherdak MA
- Журнал: Journal of Molecular and Genetic Medicine
- Том: 10
- Номер: 4
- Год издания: 2016
- Издательство: Library Pub. Media
- Местоположение издательства: Oxford, UK, England
- Первая страница: 1
- Последняя страница: 6
- DOI: 10.4172/1747-0862.1000236
- Аннотация: The receptors, whose ligand interaction activation was previously considered to be associated with initiation of apoptosis only, can have a range of biological effects: apoptosis, inflammation, proliferation, and differentiation. Therefore, interaction between death receptor and its ligand does not always mean the initiation of programmed cell death and blocking of this ligand-receptor interaction can affect the initiation of recovery and neuroplasticity mechanisms. Fas is one of these death receptors. The following review represents data on the conditions of Fasdependent signal pathways induction in ischemic stroke. There is a possibility for the development of new target neuroprotective drugs with selective effects on different separated signal pathways, activated by ligand-receptor interactions in Fas-FasL (Fas ligand) system.
- Добавил в систему: Горбачева Любовь Руфэльевна