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A Randomized phase II trial of pemetrexed plus irinotecan (ALIRI) versus leucovorin-modulated 5-FU plus irinotecan (FOLFIRI) in first-line treatment of locally advanced or metastatic colorectal cancerстатья
Дата последнего поиска статьи во внешних источниках: 4 марта 2022 г.
- Авторы: Underhill, (Underhill Craig, Goldstein Craig), (Goldstein David, Gorbounova David), (Gorbounova Vera A., Biakhov Vera A.), (Biakhov Mikhail Y., Bazin Mikhail Y.), (Bazin Igor S., Granov Igor S.), (Granov Dmitry A., Hossain Dmitry A.), (Hossain Anwar M., Blatter Anwar M.), (Blatter Johannes, Kaiser Johannes), (Kaiser Christopher, Ma Christopher), (Ma Doreen, Doreen)
- Журнал: Journal of Oncology
- Том: 73
- Номер: 1-2
- Год издания: 2007
- Издательство: Hindawi Publishing Corporation
- Местоположение издательства: United States
- Первая страница: 9
- Последняя страница: 20
- DOI: 10.1159/000120626
- Аннотация: AbstractBackground: This multicenter, randomized trial compared overall response rate between pemetrexed plus irinotecan ( ALIRI) and leucovorin-modulated 5-fluorouracil plus irinotecan (FOLFIRI) in patients with advanced colorectal cancer. Secondary objectives included overall and progression-free survival, duration of response, toxicities, and biomarkers. Patients and Methods: ALIRI patients received pemetrexed 500 mg/m(2) and irinotecan 350 mg/m(2) with vitamin supplementation on day 1 of each 21-day cycle. FOLFIRI patients received irinotecan 180 mg/ m 2 on days 1, 15, 29; on days 1, 2, 15, 16, 29, 30, patients received leucovorin 200 mg/ m 2, bolus 5-fluorouracil 400 mg/m(2), and 5-fluorouracil 600 mg/m(2) as 22-hour infusion. Results: Of 132 patients randomly assigned, 130 patients ( 64=ALIRI, 66=FOLFIRI) received 6 1 dose of treatment. Response rates (ALIRI=20.0%, FOLFIRI = 33.3%) were not significantly different between arms ( p = 0.095). Progression-free survival was 5.7 months for ALIRI and 7.7 months for FOLFIRI ( p < 0.001). Neutropenia, fatigue, diarrhea, nausea, and vomiting were the major toxicities.There were 5 drug-related deaths (ALIRI=4, FOLFIRI=1). Biomarker analysis failed to reveal that any of the 18 preselected genes were clearly associated with tumor response. Conclusions: Neither efficacy nor safety improved on the ALIRI arm compared to the FOLFIRI arm. Progression-free survival on FOLFIRI was significantly longer compared to ALIRI. Potential biomarkers capable of predicting response to either regimen in advanced or metastatic colorectal carcinoma need further characterization. Copyright (c) 2008 S. Karger AG, Basel.
- Добавил в систему: Базин Игорь Сергеевич