Аннотация:New derivatives of 5-bromo-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)cyclopent-2-enone in combination with different derivatives of aromatic aldehydes have been proposed as potential Tubulin/Tdp1 inhibitors. Precursors for cyclopentadienothiazole condensation were obtained by described in literature methods with yields of 55- 86% and were characterized by 1H NMR spectra.