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Elastic and Non-elastic Properties of Cadherin Ectodomain: Comparison with Mechanical Systemстатья
- Авторы: Likhachev I.V., Balabaev N.K., Galzitskaya O.V.
- Сборник: International Conference on Computer Science, Engineering and Education Applications ICCSEEA 2019: Advances in Computer Science for Engineering and Education II
- Серия: Advances in Intelligent Systems and Computing
- Год издания: 2020
- Первая страница: 555
- Последняя страница: 566
- Аннотация: Cadherins are predominantly homotypically acting cell-cell adhesion molecules that play an essential role in animal differentiation and maintenance of tissue integrity. Their cell-cell adhesive function relies on the presence of Ca2+ but is also influenced by other ions, in particular Mg2+. Initial studies were devoted to analysis of the influence of various cations on cadherin-mediated cell-cell adhesion, and the subsequent work is focused predominantly on the role of Ca2+, disregarding other physiologically relevant ions that are also able to form water complexes and stabilize protein conformations, i.e. Mg2+. The amino acid sequence analysis revealed earlier the presence of several putative acidic Ca2+ binding motifs that were later confirmed. Using molecular dynamics simulations we demonstrated that the cadherin ectodomain acts as a spring but also dampens pulling forces. Both the simple model system (Glu-ion-Glu) and the complex cadherin macromolecule equally demonstrate two types of behavior: the systems with potassium and sodium ions possess less mechanical stability for external force action than the systems with calcium and magnesium. https://link.springer.com/chapter/10.1007/978-3-030-16621-2_52
- Добавил в систему: Галзитская Оксана Валериановна