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Peyer's patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantationстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 сентября 2013 г.
- Авторы: Welniak LA, Kuprash DV, Tumanov AV, Panoskaltsis-Mortari A., Blazar BR, Sun K., Nedospasov SA, Murphy WJ
- Журнал: Blood
- Том: 107
- Год издания: 2006
- Издательство: American Society of Hematology
- Местоположение издательства: United States
- Первая страница: 410
- Последняя страница: 412
- DOI: 10.1182/blood-2004-11-4565
- Аннотация: Graft-versus-host disease (GVHD) is a multistep disease process following allo- geneic bone marrow transplantation (BMT). It has been postulated that the induction of acute GVHD requires the presence of Peyer patches (PPs). A new tumor necrosis factor (TNF)–deficient strain has been developed that totally lacks PPs and displays the defects characteristic of TNF ablation but not lympho- toxin-associated defects characterized by lack of both PPs and lymph nodes. To determine the necessity of PPs in acute lethal GVHD induction, we transplanted full major histocompatibility complex (MHC)–mismatched grafts into myeloab- lated TNF knockout recipients. No differ- ences in the survival or GVHD-associated histopathologic lesions were observed between the recipients. We conclude that neither PPs nor host TNF-���� is required for the development of acute lethal GVHD in mice that undergo myeloablative condi- tioning and allogeneic BMT.
- Добавил в систему: Недоспасов Сергей Артурович