|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Determination of the Enantiomeric Purity of Albuterol on Sorbents Modified by Macrocyclic Antibioticsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 13 июня 2017 г.
- Авторы: Shapovalova E.N., Fedorova I.A., Priporova A.A., Ananieva I.A., Shpigun O.A.
- Журнал: Moscow University Chemistry Bulletin
- Том: 72
- Номер: 1
- Год издания: 2017
- Издательство: Allerton Press Inc.
- Местоположение издательства: United States
- Первая страница: 56
- Последняя страница: 62
- DOI: 10.3103/S0027131417010138
- Аннотация: The separation of albuterol enantiomers on sorbents with macrocyclic glycopeptide antibiotics immobilized on the silica surface was investigated. Commercial columns—Nautilus-E (BioKhimMak, Russia) with eremomycin as a chiral selector and ChirobioticTAG (Astec, United States) with teicoplanin aglycone as a chiral selector—were used for enantioseparation. Levalbuterol is the (R)-enantiomer of albuterol. We managed to separate albuterol enantiomers on both columns in a polar organic mode, but selectivity was higher on the ChirobioticTAG column (Rs = 1.7). The maximum resolution of enantiomer peaks (1.7) was observed in methanol–acetonitrile–triethylamine–acetic acid (90 : 10 : 0.05 : 0.05) as the mobile phase. The detection limit of the compound calculated by a signal–background ratio of 3 : 1 was 0.00002 mg/mL, which corresponds to 0.1% of (S)-enantiomer with respect to the total amount. The results made it possible to determine the enantiomeric purity of the active pharmaceutical substances of levalbuterol.
- Добавил в систему: Ананьева Ирина Алексеевна