Nanoemulsions Containing Incorporated Lipophilic Drug, Felodipine, and Microheterogeneous Adhesive Polymer Matrices Based on These Nanoemulsionsстатья
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Дата последнего поиска статьи во внешних источниках: 1 июня 2022 г.
Аннотация:Oil-in-water nanoemulsions (NEs) have been obtained with a simple composition, in which a lipophilic non-micelle-forming nonionic surfactant (Tween 85) serves as both a dispersed phase and a stabilizer.The NEs remain in a metastable state for a long time (several months) and have a highly developed specific surface area (Ssp ≅ 63 m2/g) and a high solubilization capacity with respect to a lipophilic hypotensive drug, felodipine (FD). Nanosized droplets (dav ≅ 95 nm) of the NEs efficiently transport FD in an aqueous medium. The oil-in-water NEs of Tween 85 with incorporated FD and a solution of a polymer adhesive (a blend of polyisobutylenes having different molecular weights and polybutene) in heptane have been used to obtain oil1/water/oil2 double emulsions, which are used as premixes for polymer microheterogeneous matrices. Obtained polymer films are characterized by a good adhesion to skin, the absence of FD crystallization, and a constant rate of its release for several hours.