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The inhibitory effect of dinitrosyl iron complexes (NO donors) on myeloperoxidase activityстатья
- Авторы: Akentieva* N.P., Sanina N.A., Gizatullin A.R., Shmatko N.Y., Goryachev N.S., Shkondina N.I., Prikhodchenko T.R., Aldoshin S.M.
- Журнал: Doklady Biochemistry and Biophysics
- Том: 477
- Год издания: 2017
- Издательство: M A I K Nauka - Interperiodica
- Местоположение издательства: Russian Federation
- Первая страница: 1
- Последняя страница: 5
- DOI: 10.1134/S1607672917060126
- Аннотация: bstract—The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with func-tional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, andtheir efficiency was evaluated. It was shown that the enzyme MPO is the molecular target of DNICs. It wasfound that six DNICs inhibited the activity of MPO and one compound potentiated it. The evaluation of theirefficiency showed that two DNICs effectively inhibited the activity of MPO by 50% at IC50 = 2 × 10–4 M andIC50 = 5 × 10–7 M.
- Добавил в систему: Шкондина Наталья Ивановна