|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Continuum Modeling of Cell Sorting within a Plane Layer with Account for the Possible Separation of the Boundaries of the Regions Occupied by Cells of Two Different Typesстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 6 июля 2022 г.
- Авторы: Logvenkov S.A., Stein A.A.
- Журнал: Fluid Dynamics
- Том: 57
- Номер: 3
- Год издания: 2022
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 221
- Последняя страница: 233
- DOI: 10.1134/S0015462822030090
- Аннотация: In aggregates formed by cells of different types, the phenomenon of their sorting is observed: as a result of cell interactions, structures develop in which cells of one type can form a compact mass surrounded by cells of another type. The physical mechanisms underlying the sorting process are still the subject of discussion. We have previously proposed a continuum model of a biological continuum formed by two actively interacting cell phases and a fluid. Based on this model, a model problem of redistribution of cells of two types, which fill an infinite plane layer, was considered under the assumption that two cell populations are bounded by a common outer boundary. In the proposed study, a similar problem is formulated and investigated, taking into account the possible relative displacement of surfaces that bound cells of different types. This formulation allows us to describe the formation and propagation of fronts separating regions that differ in the concentrations of cell phases. The behavior of solutions is studied depending on the dimensionless parameters characterizing active intercellular interactions. The participation of these mechanisms in the formation of new cellular structures was analyzed numerically. It has been shown that, in a wide range of parameters, cells with stronger contracting active interactions tend to occupy the central region, displacing cells with weaker contracting interactions to the periphery. The novel formulation is physically more adequate and allows us to expand the range of parameters in which a stable result is achieved.
- Добавил в систему: Штейн Александр Александрович