Аннотация:Background: There is increasing evidence of serious deterioration in long-term Quality of Life (QoL) in COVID-19 intensive care unit (ICU) survivors.
Goal of Study: to estimate the QoL of ICU sur vivors six months af ter discharge from COVID hospital and to highlight some factors re- sponsible for that kind of outcome.
Materials and Methods: a prospective E-questionnaire of patients was carried out with SF-36 scale [1,2]. All essential data related to physical (PC) and mental (MC) components of the QoL were identi- fied, collected, and analyzed. Multivariable regression was chosen to identify predictors to impact the QoL.
Results and Discussion: Only 125 patients of 222 ICU survivors agreed to sign the Informed Consent of the survey. We proceeded from the fact that normal level of QoL according to SF-36 guide are “≥50 relative units“, both, for PC and MC . Accounting to that base- line, 68% of patients been followed up had a reduced PC and 48% MC of QoL.
Among all therapies had been available during first wave of Pan- demic, it was Low Molecular Weight Heparin only, been able to im- prove PC of patients’ QoL (odds ratio: 3.341 (95% CI: 1.298-8.599, p = 0.012).
At last, but not least, age ≥ 52 years (odds ratio: 0.223, p = 0.001) and female gender (odds ratio: 0.321, p = 0.02) were associated with declining physical health. A history of cerebrovascular insuf- ficiency has been associated with a decrease in the mental health component of QoL (odds ratio: 0.125, p = 0.002).
Conclusion(s): 1) 68% of ICU survivors been followed up to 6 months af ter COVID hospital discharge had a reduced physical and 48% mental components of Quality of Life 2) ICU Low Molecular Weight Heparin treatment appeared to be the single one predictor of improvement in the physical component of quality of life in patients with COVID-19 six months after hospital discharge.