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Assessment of the Human Metabolome as a Method for Molecular Diagnostics of Colorectal Cancer: Prevention and Therapyстатья
- Авторы: Shilovsky G.A., Sorokina E.V., Putyatina T.S.
- Журнал: Biology Bulletin Reviews
- Том: 12
- Номер: 4
- Год издания: 2022
- Издательство: Pleiades Pub.
- Местоположение издательства: Tortola, British Virgin Islands, British Virgin Islands
- Первая страница: 422
- Последняя страница: 427
- Оригинальные версии: Оценка метаболома человека как метод молекулярной диагностики колоректального рака. Профилактика и терапия
- DOI: 10.1134/S2079086422040089
- Аннотация: Abstract—The analysis of the metabolome is a key point for understanding the dynamic processes occurringin the organism. Under normal conditions, the concentration of certain compounds in tissues is determinedby their role in metabolic processes and, as a rule, varies within small limits. However, with pathology, themetabolic profile of the affected tissue can change dramatically. By studying the dynamics of the compositionand concentration of metabolites, one can understand the molecular basis of the occurrence of many diseases, or at least identify their biomarkers. This review focuses on the relationship between intestinal flora andcolorectal cancer; however, the exact mechanism of the intestinal flora that causes this type of cancer is stillunclear. Data from the literature indicate the role of metabolites of probiotic cultures: cleavage products ofproteins, carbohydrates (in particular lactose), peptide bacteriocins, antioxidants, and compounds that function as neurotransmitters and neurohormones. These substances act as signaling molecules within the microbial consortium and at the same time affect the host as a whole. Microorganisms favorable for human health(lactobacilli, bifidobacteria and lactic streptococci) used as probiotics form a natural immune defense, accelerate the process of regeneration of the epithelium, and also take an active part in the process of phagocytosis,showing high efficiency in the treatment of various diseases of the gastrointestinal tract. Thus, it is importantto maintain a balance between these microorganisms and opportunistic bacteria. They may also be used asprobiotics in the prevention and early detection of colorectal cancer.Keywords: metabolome, metabolites, colorectal cancer, lactobacilli, probiotics, diagnostics.
- Добавил в систему: Сорокина Елена Владимировна