|
ИСТИНА |
Войти в систему Регистрация |
ФНКЦ РР |
||
Участие пептида PGPL в восстановлении функции противосвертывающей и инсулярной систем организма при развитии стойкой гипергликемии у крысстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из перечня ВАК- Авторы: Оберган Т.Ю., Шубина Т.А., Григорьева М.Е., Ляпина Л.А., Мясоедов Н.Ф., Андреева Л.А.
- Журнал: Вопросы биологической, медицинской и фармацевтической химии
- Номер: 4
- Год издания: 2013
- Издательство: Общество с ограниченной ответственностью Издательский дом Русский врач
- Местоположение издательства: Москва
- Первая страница: 38
- Последняя страница: 42
- Аннотация: Influence of peptide Pro-Gly-Pro-Leu on hemostatic and insular systems of organism at the experimental hyperglycemia, like the type 2 diabetes mellitus is investigated. It has been established that intranasal introduction Pro-Gly-Pro-Leu (1 mg/kg body weight, per day over 4 days)to rats with a proof hyperglycemia led to increase anticoagulant and fibrinolytic plasma potential of animal blood and decrease in blood glucose level. Strengthening fibrinolytic properties of plasma occurred as at the expense of increase total and non-enzymatic fibrinolysis, and increases of tissue plasminogen activator activity. In these conditions the peptide did not show antiplatelet activity. In the further experiments 5-fold intranasal introduction of Pro-Gly-Pro-Leu to rats at a dose 1 mg/kg 2 times a day against development of a proof hyperglycemia led to normalization of impaired anticoagulant and insular systems of organism. So the investigated peptide rendered not only hypoglycemic actions and raised anticoagulant and fibrinolytic plasma potential of animal blood, but also led to decrease of platelet aggregation. Thus hemostasis parameters and blood glucose level were restored to values which are characteristic for healthy animals. Proof hypoglycemic effect and increase of anticoagulant blood potential remained throughout five days after the abolition of peptide treatment.
- Добавил в систему: Ляпина Людмила Анисимовна