Аннотация:Comparison of the healing rates of different wound types using natural andsynthetic polymers, containing silver nanoparticles. Experimental purulentand aseptic wounds are created on white rats. In the course of treatment,dressings are performed daily, including photographing the wound andapplying various types of nanocomposite polymer materials. Cotton gauze,which is a polysaccharide, is taken as a natural polymer. The syntheticpolymer is a nonwoven hydro-bonded polypropylene material produced byextrusion of polypropylene filaments. Silver nanoparticles used in the studyare obtained by the metal-steam synthesis method. It is found that in allanimals with aseptic or purulent created wound in the first 4 days of theexperiment, an increase in the area of the wound is observed with respect tothe initial one, much less pronounced in the presence of silver nanoparticlesin the material. On the following days of treatment, up to complete healing,the decrease in the wound area in relation to the initial one in theexperimental group (with silver nanoparticles) occurs more intensively than inthe control group of animals (p < 0.05). Both natural and synthetic polymericmaterials coated with silver nanoparticles synthesized by metal-steamsynthesis method accelerate the healing of both experimental aseptic andpurulent wounds. However, the rate of wound healing when using natural orsynthetic materials differs depending on the type of wound and the presenceof microbial contamination, which should be taken into account whencreating a new generation of dressings.
