Synthesis and evaluation of the anticancer activity of the water-dispersible complexes of 4-acylaminoisoxazole derivative with biocompatible nanocontainers based on Ca2+ (Mg2+) cross-linked alginateстатья
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Аннотация:Isoxazole derivatives represent an important class of N,O-heterocyclic compounds which has found numerous applications in organic and medicinal chemistry. Isoxazole moiety is of particular interest as a core of natural products (e.g., ibotenic acid, muscimol), marketed drugs (oxacillin, valdecoxib,isocarboxazid and many others) and compounds with a broad range of biological activities. Also, isoxazole derivatives have found application in design of drug candidates for cancer therapy. Isoxazole derivatives containing various substituents and functional groups are generally characterized by high hydrophobicity. So, they are poorly soluble in aqueous media, that limits the possibilities for their biomedical application. Due to this fact, as well as to the ability of isoxazoles to exert a toxic effect not only on cancer, but also on normal cells, the problem of obtaining water-dispersible forms of isoxazole derivatives and their controlled administration only to cancer cells is extremely relevant.
