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Synthesis, cytotoxicity and antiviral activity studies of the conjugates of cobalt bis(1,2-dicarbollide)(-I) with 5-ethynyl-2'-deoxyuridine and its cyclic derivativesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 марта 2017 г.
- Авторы: Ilinova A., Semioshkin A., Lobanova I., Bregadze V.I., Mironov A.F., Edyta Paradowska E., Studzińska M., Jabłońska A., Białek-Pietras M., Leśnikowski Z.J.
- Журнал: Tetrahedron
- Том: 70
- Год издания: 2014
- Издательство: Pergamon Press Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 5704
- Последняя страница: 5710
- DOI: 10.1016/j.tet.2014.06.072
- Аннотация: A series of novel conjugates of cobalt bis(1,2-dicarbollide)(-I) with 5-ethynyl-2'-deoxyuridine and its cyclic derivatives were synthesized. Conjugates with 5-ethynyl-2-deoxyuridine were prepared by the direct Sonogashira coupling of a series of cobalt bis(1,2-dicarbollide)(-I) terminal alkynes and 5-iodo-2'-deoxyuridine. Their furo[2,3-d]pyrimidin-2(3H)-one isomers were obtained either by intermolecular cyclization of the above conjugates or by Sonogashira coupling using Pd/C as a catalyst. Action of ammonia on these furo[2,3-d]pyrimidin-2(3H)-one conjugates resulted in pyrrolo[2,3-d]pyrimidin-2(3H)-one conjugates. Most of the designed compounds have shown low cytotoxity in several cell lines. Some 5-ethynyl-2-deoxyuridine and furo[2,3-d]pyrimidin-2(3H)-one conjugates have also presented antiviral activity.
- Добавил в систему: Семиошкин Андрей Анатольевич