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Reactions of closo-dodecaborate amines. Towards novel bis-(closo-dodecaborates) and closo-dodecaborate conjugates with lipids and non-natural nucleosidesстатья
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 августа 2017 г.
- Авторы: Laskova J., Kozlova A., Białek-Pietras M., Studzińska M., Paradowska E., Bregadze V., Leśnikowski Z.J., Semioshkin A.
- Журнал: Journal of Organometallic Chemistry
- Том: 807
- Год издания: 2016
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 29
- Последняя страница: 35
- DOI: 10.1016/j.jorganchem.2016.02.009
- Аннотация: Alkylation, acylation and arylation reactions of closo-dodecaborate based amines were studied. First, bis-(closo-dodecaborate) species with terminal amino group tethered via linkers of different types were prepared by cleavage of cyclic oxonium adducts of closo-dodecaborate with closo-dodecaborate tertiary amines. Acylation of [B12H11OCH2CH2OCH2CH2N+H3]2- with fatty acid acyl chlorides afforded new closo-dodecaborate lipid amides. Reaction of [B12H11OCH2CH2OCH2CH2N+H3]2- with 4-chloro-1-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine followed by removal of protecting groups from the sugar residue resulted in the first conjugate of closo-dodecaborate with non-natural 8-aza-7-deaza-2’-deoxyadenosine nucleoside analog
- Добавил в систему: Семиошкин Андрей Анатольевич