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Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functionsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Skvortsova Y.V., Kondratieva S.A., Zinovyeva M.V., Nikolaev L.G., Azhikina T.L., Gainetdinov I.V.
- Журнал: PLoS ONE
- Том: 11
- Номер: 6
- Год издания: 2016
- Издательство: Public Library of Science
- Местоположение издательства: United States
- Первая страница: e0156454
- Аннотация: Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies broader impact on understanding enhancer-promoter networks in regulation of gene expression.
- Добавил в систему: Николаев Лев Григорьевич