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Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccineстатья
- Авторы: Hawley K.L., Montezuma-Rusca J.M., Delgado K.N., Singh N., Uversky V.N., Caimano M.J., Radolf J.D., Luthra A.
- Журнал: Japanese Journal of Bacteriology
- Том: 203
- Номер: 15
- Год издания: 2021
- Издательство: Business Center for Academic Societies Japan/Nihon Gakkai Jimu Senta
- Местоположение издательства: Japan
- Первая страница: e0008221
- Аннотация: The unusual outer membrane (OM) of T. pallidum, the syphilis spirochete, is the ultrastructural basis for its well-recognized capacity for invasiveness, immune evasion, and persistence. In recent years, we have made considerable progress in identifying T. pallidum’s repertoire of OMPs. Here, we developed three-dimensional (3D) models for the T. pallidum Nichols OMPeome using structural modeling, bioinformatics, and solution scattering. The OM contains three families of OMP transporters, an OMP family involved in the extrusion of noxious molecules, and two "stand-alone" proteins involved in OM biogenesis. This work represents a major advance toward elucidating host-pathogen interactions during syphilis; understanding how T. pallidum, an extreme auxotroph, obtains a wide array of biomolecules from its obligate human host; and developing a vaccine with global efficacy.
- Добавил в систему: Уверский Владимир Николаевич