Protective effect of D-panthenol in rhabdomyolysis-induced acute kidney injury

Semenovich, D.S.; Plotnikov, E.Y.; Lukiyenko, E.P.; Astrowski, A.A.; Kanunnikova, N.P.

Авторы: Semenovich Dmitry S., Plotnikov Egor Y., Lukiyenko Elena P., Astrowski Alexander A., Kanunnikova Nina P.
Журнал: International Journal of Molecular Sciences
Том: 23
Номер: 19
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
DOI: 10.3390/ijms232012273
Аннотация: We investigated the nephroprotective effect of D-panthenol in rhabdomyolysis-induced acute kidney injury (AKI). Adult male Wistar rats were injected with 50% glycerol solution to induce rhabdomyolysis. Animals with rhabdomyolysis were injected with D-panthenol (200 mg/kg) for 7 days. On day 8, we examined AKI markers, renal histology, antioxidant capacity, and protein glutathionylation in kidneys to uncover mechanisms of D-panthenol effects. Rhabdomyolysis kidneys were shown to have pathomorphological alterations (mononuclear infiltration, dilatation of tubules, hyaline casts in Henle's loops and collecting ducts). Activities of skeletal-muscle damage markers (creatine kinase, lactate dehydrogenase) increased, myoglobinuria was observed; creatinine, BUN, pantetheinase activity in serum and urine rose. Signs of oxidative stress in the kidney tissue of rhabdomyolysis rats, increased levels of lipid peroxidation products, activities of antioxidant enzymes (SOD, catalase, glutathione peroxidase) were all alleviated by administration of D-panthenol. Its application improved kidney morphology and decreased AKI markers. Mechanisms of D-panthenol beneficial effects were associated with an increase in the total coenzyme A levels, activity of Krebs cycle enzymes, and attenuation of protein glutathionylation. D-Panthenol protects kidney from rhabdomyolisis-induced AKI through antioxidant effects, normalization of mitochondrial metabolism and modulation of glutathione-dependent signaling.
Добавил в систему: Плотников Егор Юрьевич

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Protective effect of D-panthenol in rhabdomyolysis-induced acute kidney injuryстатья

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