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Chitosan- g -oligo/polylactide copolymer non-woven fibrous mats containing protein: from solid-state synthesis to electrospinningстатья
- Авторы: Demina Tatiana S., Kuryanova Anastasia S., Aksenova Nadejda A., Shubnyy Andrey G., Popyrina Tatiana N., Sokovikov Yaroslav V., Istranova Elena V., Ivanov Pavel L., Timashev Peter S., Akopova Tatiana A.
- Журнал: RSC advances
- Том: 9
- Номер: 64
- Год издания: 2019
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- Первая страница: 37652
- Последняя страница: 37659
- DOI: 10.1039/c9ra07667k
- Аннотация: Graft-copolymers based on bioresorbable synthetic (oligo-/polylactide) and natural (chitosan and collagen/gelatin) components were synthesized through solid-state reactive co-extrusion and used for fabrication of fibrous non-woven mats via the electrospinning technique. The effect of the macromolecular features of the initial components on the copolymer characteristics was evaluated using FTIR-spectroscopy, differential scanning calorimetry and elemental analysis. Dynamic light scattering analysis showed that the copolymers have a tendency to form stable ultra-fine dispersions with a mean size of macromolecular aggregates of 150 nm within chlorinated solvents. The copolymer-containing non-woven fibrous mats were fabricated via an electrospinning procedure using chloroform as a solvent. An effect of the copolymer composition on the casting solution's viscosity, conductivity and surface tension was evaluated. Scanning electron microscopy showed that the obtained mats consist of randomly distributed fibers with a mean size of ∼5 μm and a more complex morphology than mats fabricated from neat polylactide. The proposed mechanochemical approach to obtain hybrid copolymeric compositions differs from typical liquid-phase methods in terms of high efficiency, simplicity and cleanness.
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