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Influence of Obesity and Its Metabolic Type on the Serum Concentration of Neurotrophinsстатья
- Авторы: Kolesnikovaa I.M., Rumyantseva S.A., Volkova N.I., Gaponov A.M., Grigor’eva T.V., Laikove A.V., Makarov V.V., Yudin S.M., Borisenkoa O.V., Shestopalov A.V.
- Журнал: Neurochemical Journal
- Том: 16
- Номер: 2
- Год издания: 2022
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 200
- Последняя страница: 206
- DOI: 10.1134/S1819712422020088
- Аннотация: Damage to the nervous system is a common complication of obesity. In this regard, analysis of the content of neurotrophins in patients with obesity seems relevant. However, the risk of complications is determined by the metabolic type of the obesity, so our aim was to study the effect of the metabolic type of obesity on the content of neurotrophins in the blood serum. We found that the content of brain-derived neurotrophic factor (BDNF) does not change in obesity, but the serum concentration of nerve growth factor (NGF) significantly decreases, regardless of the metabolic type of obesity. Taking into account the literature data that obesity is accompanied by an increase in the plasma concentration of NGF, it may be assumed that obesity is associated with a disruption of NGF deposition in platelets and, as a result, acceleration of its elimination. At the same time, in patients with metabolically unhealthy obesity (MUO), the content of NGF was higher than in patients with metabolically healthy obesity (MHO). We also showed that muscle and adipose tissues make a significant contribution to the formation of the serum NGF pool in MHO. However, in MUO patients, the influence of adipose tissue on NGF content prevailed. In addition, in patients with MUO, we noted an effect of the secretory activity of muscle tissue on the content of BDNF, while in patients with MHO this effect was not observed.
- Добавил в систему: Гапонов Андрей Михайлович