Аннотация:Obesity is associated with a gut microbiome imbalance and the risk of neurological complications. However, the risk of complications is determined by the metabolic type of obesity. The aim was to study the effect of intestinal microbiome taxa on the content of neurotrophins. 130 healthy non-obese donors and 104 obese patients were examined. Depending on the metabolic type of obesity, patients were divided into subgroups with metabolically healthy obesity (MHO, n = 40) and metabolically unhealthy obesity (MUHO, n = 55). Serum concentrations of neurotrophins were measured, and the gut microbiome qualitative assessment was determined by sequencing of the variable region of the 16S rRNA gene. Taxa with a positive correlation with brain-derived neurotrophic factor (BDNF) concentration were mainly represented by butyrate and/or GABA-producing microorganisms capable of degrading mucin. In healthy donors, a positive relationship was found between BDNF and S24-7. BDNF association with Bacteroides spp., Rikenellaceae, Oscillospira spp., [Barnesiellaceae], B. ovatus and Anaerostipes spp. was noted in MHO, while in MUHO with Bifidobacterium spp. and Coprococcus spp. Taxa negatively correlated with BDNF have also been identified, predominantly Gram-positive in obese patients. Nerve growth factor (NGF) concentration has been associated with the gut microbiome in obesity but not in healthy donors. A positive relationship with NGF has been noted for Odoribacter spp. in MHO patients and Slackia spp. in MUHO patients. H. parainfluenzae, Erysipelotrichaceae, Megamonas spp. and Clostridiaceae had a negative association on NGF level in MHO. In MUHO, a similar effect was shown by ML615J-287 and Clostridiales. Thus, obesity, regardless of metabolic type, is associated with the appearance of the “gut microbiome—NGF” relationship, which, apparently, is a consequence of increased intestinal permeability. The list of taxa that correlated with neurotrophins was unique for each group of patients. The obtained results indicate a significant effect ofinter-taxa interaction on the neurotrophin level.