Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives

Авторы: Gracheva Iuliia A., Shchegravina Ekaterina S., Schmalz Hans-Günther, Beletskaya Irina P., Fedorov Alexey Yu
Журнал: Journal of Medicinal Chemistry
Том: 63
Номер: 19
Год издания: 2020
Издательство: American Chemical Society
Местоположение издательства: United States
Первая страница: 10618
Последняя страница: 10651
DOI: 10.1021/acs.jmedchem.0c00222
Аннотация: Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its pharmacological potential as a lead structure is not yet fully exploited. This review is devoted to the synthesis and structure-activity relationships (SAR) of colchicine alkaloids and their analogues with modified A, B, and C rings, as well as hybrid compounds derived from colchicinoids including prodrugs, conjugates, and delivery systems. The systematization of a vast amount of information presented to date will create a paradigm for future studies of colchicinoids for neoplastic and various other diseases.
Добавил в систему: Белецкая Ирина Петровна

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