Complexation of oligochitosan with sodium caseinate in alkalescent and weakly acidic media

Авторы: Antonov Y.A., Zhuravleva I.L., Bezrodnykh E.A., Berezin B.B., Kulikov S.N., Tikhonov V.E.
Журнал: Carbohydrate Polymers
Том: 302
Номер: 15
Год издания: 2023
Издательство: Pergamon Press Ltd.
Местоположение издательства: United Kingdom
Номер статьи: 120391
DOI: 10.1016/j.carbpol.2022.120391
Аннотация: Сomplexation of oligochitosan (OCHI) having the degree of acetylation (DA 26%) with sodium caseinate (SC) at pH 5.8 and 7.2 is described and compared with the complexation of OCHI (DA 2%) at pH 5.8. In the alkalescent medium, the complexation of OCHI (DA 26%) is weaker and dualistic depending on SC concentration in the system. In the diluted alkalescent system, the formation of only soluble complexes is observed at OCHI/SC ratio ≤0.9. In the semi diluted one, the complexation results in the formation of insoluble complexes those composition changes symbatically with the OCHI/SC ratio in the system. At pH 5.8, OCHI/SC ratio in insoluble complexes remains the same regardless of OCHI/SC ratio in the solution. At pH 5.8, the electrostatic complexation weakens with an increase in DA and is completely suppressed at a high ionic strength. These results can be promising for construction of biodegradable protein/chitosan drug delivery systems.
Добавил в систему: Тихонов Владимир Евгеньевич

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