Аннотация:The purpose of the article is to carry out the analysis of interrelatedness of cities inthe territorial space of Russia. The evaluation method is based on the calculation ofglobal and local Moran’s indexes for determination of interrelatedness of the adjacentterritories by the following parameters: "population size", "population density", "averagemonthly salary", "shipping volume per capita". Represented as the study object werecities of the Volga Federal District of Russia with a population size over 100 thousandpeople in 2017. As a result of the calculations performed the leading cities weredetermined for all researched parameters. The quantitative evaluations obtained by theauthors can be used for investigation of the leading cities effects and determination ofthe region development strategies