New Azido Coumarins as Potential Agents for Fluorescent Labeling and Their “Click” Chemistry Reactions for the Conjugation with closo-Dodecaborate Anion

Авторы: Laskova Julia, Serdyukov Alexander, Kosenko Irina, Ananyev Ivan, Titova Ekaterina, Druzina Anna, Sivaev Igor, Antonets Anastasia A., Nazarov Alexey A., Bregadze Vladimir I.
Журнал: Molecules
Том: 27
Номер: 23
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 8575
DOI: 10.3390/molecules27238575
Аннотация: Novel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained coumarins have been tested with closo-dodecaborate derivative bearing terminal alkynyl group. CuI catalyzed Huisgen 1,3-dipolar cycloaddition reaction has led to fluorescent conjugates formation. The absorption–emission spectra of the formed conjugates have been presented. The antiproliferative activity and uptake of compounds against several human cell lines were evaluated.
Добавил в систему: Назаров Алексей Анатольевич

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