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A Three-Component Synthesis of 3-Functionally Substituted 5,6-Dihydropyrrolo[2,1-a]isoquinolinesстатья
- Авторы: Miftyakhova A.R., Borisova T.N., Titov A.A., Sidakov M.B., Novikov R.A., Efimov I.V., Varlamov A.V., Voskressensky L.G.
- Журнал: Chemistry and Biodiversity
- Том: 19
- Номер: 1
- Год издания: 2022
- Издательство: Verlag Helvetica Chimica Acta
- Местоположение издательства: Switzerland
- DOI: 10.1002/cbdv.202100584
- Аннотация: Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active. © 2021 Wiley-VHCA AG, Zurich, Switzerland
- Добавил в систему: Малошицкая Ольга Александровна