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The Effect of Lysophosphatidic Acid on the Composition of Cytoplasmic Protein Complexes that Contain Myosin-9 and Tropomyosinстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 21 августа 2017 г.
- Авторы: Bobkov D.E., Kropacheva I.V.
- Журнал: Cell and Tissue Biology
- Том: 11
- Номер: 3
- Год издания: 2017
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 197
- Последняя страница: 204
- DOI: 10.1134/S1990519X17030026
- Аннотация: The present article reports immunofluorescence-based analysis of the distribution of the actin- binding protein myosin-9 in the cytoplasm of human embryonic lung fibroblasts. Electrophoresis and Western blotting were used to demonstrate that myosin-9, actin, and high molecular weight tropomyosin isoforms of are incorporated into cytoplasmic protein complexes not bound to cytoskeletal structures. Cross-immunoprecipitation was used to show that these complexes were rapidly disassembled when the cells were exposed to lysophosphatidic acid (LPA). Moreover, LPA induced proteolytic degradation of myosin-9 associated with the structures of the actin cytoskeleton. The results obtained point at the participation of multimolecular cytoplasmic protein complexes that contain myosin-9 and tropomyosin in the regulation of the cellular response to stimulation with LPA.
- Добавил в систему: Бобков Данила Евгеньевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | BioCeTi1703002BobkovKOR.pdf | 6,7 МБ | 1 апреля 2017 [dan.bobkov] |