Аннотация:The multicomponent green methodologies are an ideal instrument in organic synthesis. Environmentally benign, facile, and efficient multicomponent synthesis of [(2H-pyran-3-yl)(aryl)methyl]-1,3-dimethylpyrimidines by the reaction of aromatic aldehydes, N,N′-dimethylbarbituric acid and 4-hydroxy-6-methyl-2H-pyran-2-one employing simple and eco-friendly catalyst and solvent—sodium acetate and ethanol is reported. The reaction proceeds at reflux conditions with good and excellent yields (65%–97%). The isolation of final compounds does not require complex purification procedures. All novel synthesized compounds are characterized by 1H and 13C NMR spectroscopy, FT-IR and mass spectrometry, and elemental analysis. The [(2H-pyran-3-yl)(aryl)methyl]-1,3-dimethylpyrimidine structure was proven using 2D NMR spectroscopy methods.
