T1 mapping of rat lungs in 19F MRI using octafluorocyclobutane

Pavlova, O.S.; Gulyaev, M.V.; Gervits, L.L.; Hurshkainen, A.A.; Nikulin, A.V.; Puchnin, V.M.; Teploukhova, E.D.; Kuropatkina, T.A.; Anisimov, N.V.; Medvedeva, N.A.; Pirogov, Y.A.

Авторы: Pavlova Olga S., Gulyaev Mikhail V., Gervits Lev L., Hurshkainen Anna A., Nikulin Anton V., Puchnin Viktor M., Teploukhova Ekaterina D., Kuropatkina Tatyana A., Anisimov Nikolay V., Medvedeva Nataliya A., Pirogov Yury A.
Журнал: Magnetic Resonance in Medicine
Том: 89
Номер: 6
Год издания: 2023
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Первая страница: 2318
Последняя страница: 2331
DOI: 10.1002/mrm.29606
Аннотация: The paper demonstrate the feasibility of using octafluorocyclobutane (OFCB, c-C4F8) for T1 mapping of lungs in 19F MRI. The study was performed at 7 T in three healthy rats and three rats with pulmonary hypertension. To increase the sensitivity of 19F MRI, a bent-shaped RF coil with periodic metal strips structure was used. The double flip angle method was used to calculate normalized transmitting RF field (B1n+) maps and for correcting T1 maps built with the variable flip angle (VFA) method. The ultrashort TE pulse sequence was applied for acquiring MR images throughout the study. The dependencies of OFCB relaxation times on its partial pressure in mixtures with oxygen, air, helium, and argon were obtained. T1 of OFCB linearly depended on its partial pressure with the slope of about 0.35 ms/kPa in the case of free diffusion. RF field inhomogeneity leads to distortion of T1 maps built with the VFA method, and therefore to high standard deviation of T1 in these maps. To improve the accuracy of the T1 maps, the B1n+ maps were applied for VFA correction. This contributed to a 2–3-fold decrease in the SD of T1 values in the corresponding maps compared with T1 maps calculated without the correction. Three-dimensional T1 maps were obtained, and the mean T1 in healthy rat lungs was 35 ± 10 ms, and in rat lungs with pulmonary hypertension – 41 ± 9 ms. OFCB has a spin-rotational relaxation mechanism and can be used for 19F T1 mapping of lungs. The calculated OFCB maps captured ventilation defects induced by edema.
Добавил в систему: Павлова Ольга Сергеевна

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T1 mapping of rat lungs in 19F MRI using octafluorocyclobutaneстатья Исследовательская статья

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