Wip1 phosphatase: between p53 and MAPK kinases pathwaysстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 апреля 2017 г.
Местоположение издательства:Albany, N.Y., United States
Первая страница:31563
Последняя страница:31571
Аннотация:Cells undergoing oncogenic transformation frequently inactivate tumor
suppressor pathways that could prevent their uncontrolled growth. Among those
pathways p53 and p38MAPK pathways play a critical role in regulation of cell cycle,
senescence and cell death in response to activation of oncogenes, stress and DNA
damage. Consequently, these two pathways are important in determining the
sensitivity of tumor cells to anti-cancer treatment. Wild type p53-induced phosphatase,
Wip1, is involved in governance of both pathways. Recently, strategies directed to
manipulation with Wip1 activity proposed to advance current day anticancer treatment
and novel chemical compounds synthesized to improve specificity of manipulation
with Wip1 activity. Here we reviewed the history of Wip1 studies in vitro and in vivo,
in genetically modified animal models that support Wip1 role in tumorigenesis through
regulation of p53 and p38MAPK pathways. Based on our knowledge we propose
several recommendations for future more accurate studies of Wip1 interactions with
other pathways involved in tumorigenesis using recently developed tools and for
adoption of Wip1 manipulation strategies in anti-cancer therapy.