Studies of Laser-Ablated Gold Nanoparticles as Dose Enhancers for Binary Radiotherapy of Cancerстатья
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Дата последнего поиска статьи во внешних источниках: 26 июня 2024 г.
Аннотация:Abstract—Gold nanoparticles (GNPs) are actively used as dose enhancing agents in combination withX-ray irradiation. The synthesis of gold nanoparticles by laser ablation has a number of advantages over othermethods (for example, the possibility of preparing a chemically pure solution and a relatively low productioncost when synthesis is scaled up). An additional antitumor effect from the combined use of gold nanoparticlessynthesized by laser ablation and X-rays was studied. Mice transplanted subcutaneously with Ca755 syngeneicadenocarcinoma were used for the study. The tumor was irradiated at a dose of 10 Gy in 30 min afterinjection of GNPs. As a result, 66% of complete regressions were found in the experimental group of micewithin 210 days after transplantation, while there were no regressions of tumor nodes in the control irradiatedgroup. The absorbed dose to the vascular walls with gold nanoparticles in the bloodstream was evaluated as26.8 Gy owing to local energy release.