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Poppy-seeding synapses within astrocytic domains: the role of synaptic spatial patterns in the astrocyte-neuron communicationтезисы доклада
- Авторы: Verisokin Andrey Y., Kirsanov Artem V., Verveyko Darya V., Postnov Dmitry E., Brazhe Alexey R.
- Сборник: Computational Biophysics and Nanobiophotonics
- Тезисы
- Год издания: 2022
- Место издания: SPIE
- DOI: 10.1117/12.2626037
- Аннотация: We study the effect of introducing localized synapses on the astrocyte calcium activity. Instead of homogeneous excitation we include in the model well-defined synapses as sources of glutamate. Synaptic density was scaled according to the astrocyte morphology, in particular, surface-volume ratio in accordance with experimental data. Unlike uniform excitation model, where the calcium activity was dependent only on the astrocyte morphology, different localization of synapses causes the change in baseline calcium distribution. Localization of synapses leads to the decrease of baseline calcium levels in the peripheral regions of the astrocyte, while the dynamics of thick branches and soma does not change significantly. Introduction of synapses also affects the distribution of baseline calcium levels based on AVF parameter. Supposedly, this indicates the emergence of “microdomains” - regions of the astrocyte with the highest average activity.
- Добавил в систему: Браже Алексей Рудольфович